For some patients living with cancer, clinical trials may provide new treatment avenues when they fail to respond to standard of care treatment or experience recurrence of their cancer after treatment.
UKEMS 2022 -- The ToxTracker® Assay is a panel of mouse embryonic stem cells (mES) with pathways tagged via green fluorescent protein (GFP) such that the biological reactivity and potential carcinogenic properties of novel substances can be identified. The panel of biomarkers was established following extensive genome-wide transcription profiling.
UKEMS 2022 -- Lung inflammation plays a role in the pathogenesis of various respiratory diseases such as asthma and chronic obstructive pulmonary disorder (COPD). The etiology of these diseases involves interactions between lung and immune cells, with immune cells regulating the body's response to external stimuli.
UKEMS 2022 -- The in vivo Pig-a gene mutation assay is based on the endogenous X-linked Pig-a gene, which codes for an N-acetyl glucosamine transferase that is involved in the biosynthesis of Glycosyl Phosphatidyl Inositol (GPI) anchor for tethering a variety of mammalian cell surface protein markers.
Modern challenges in the NASH clinical landscape have not diminished, but we have gained valuable, experience-based insight and extensive data on screening, recruitment, and dropout to deliver more efficient and expedited trials.
For investigator sites encountering challenges in sample collection, our Patient Service Centers offer an attractive solution. Staffed with highly trained phlebotomists, our PSCs deliver the same level of quality and consistency in results.
AACC 2022 -- Collection of 24-hr urine specimens can be challenging, especially if the urine needs to be collected using a splitter device to collect two different sample types on the same collection.
AACC 2022 -- Quality Control (QC) testing frequency is based on a number of factors such as analytical stability, error tolerance without impacting results, testing volume, etc. Less than optimal frequency can result in erroneous results, which could lead to inappropriate clinical interventions.
AACC 2022 -- Vitamin B12 is necessary for many processes in the body and is a cofactor in methylmalonic acid (MMA) metabolism. Vitamin B12 deficiency may present with few symptoms, however chronic deficiency may lead to macrocytic anemia, peripheral nerve damage and memory impairment.
