CHOP Oncology FISH

CPT: Contact CPT coding department at 800-222-7566, ext. 6-8400.
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Contact CPT coding department at 800-222-7566, ext. 6-8400.

Updated on 08/15/2022
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Synonyms

  • Leukemia FISH
  • Lymphoma FISH

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.


Expected Turnaround Time

3 - 5 days



Specimen Requirements


Specimen

Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.


Volume

Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow


Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow


Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube


Collection

Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.


Storage Instructions

Maintain specimen at room temperature.


Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen


Test Details


Use

This test is used for confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas).

Confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas)

This test is used for confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas).


Methodology

Fluorescence in situ hybridization (FISH)


Additional Information

The CHOP break-apart FISH probe is designed to rule out a rearrangement of the gene located at 12q13 associated with a reciprocal (12;16)(q13;p11) translocation (CHOP-TLS gene fusion) and myxoid/round cell liposarcoma. CHOP is fused to TLS in about 90% of myxoid liposarcomas/round cell liposarcomas.


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