Acute Myelocytic Leukemia (AML) Profile, FISH

TEST: 510336
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Test Includes

FISH for acute myelocytic leukemia (AML), targeting rearrangement of PML-RARA, CBFB, RUNX1/RUNX1T1, KMT2A and numerical changes of 5q, and 7q

Special Instructions

Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form.

Expected Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Blood, bone marrow, fixed-cell pellet from a cytogenetic analysis, or slides prepared from a cytogenetic analysis

Volume

10 mL blood (adult), 3 to 5 mL blood (pediatric), 1 to 3 mL bone marrow, one tube fixed-cell pellet, or ten slides

Minimum Volume

1 mL blood (adult/pediatric), 1 mL bone marrow, or six slides

Container

Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken Vacutainer®; broken or dirty slides; excessive cellular debris or stained slides; frozen specimen; decalcified tissue

Test Details

Use

Diagnostic and prognostic test for acute myeloid leukemia; detection rate is 80% of the known chromosome causes of AML.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probes included in this profile will not be detected.

Methodology

Fluorescence in situ hybridization (FISH)

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510336 AML FISH Panel 510709 Specimen Type 31208-2
510336 AML FISH Panel 510687 Cells Counted 62361-1
510336 AML FISH Panel 510688 Cells Analyzed 62360-3
510336 AML FISH Panel 510689 FISH Result 48674-6
510336 AML FISH Panel 510328 Interpretation 50398-7
510336 AML FISH Panel 510329 Director Review: 48672-0
510336 AML FISH Panel 512123 PDF 51967-8

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf