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Test Includes
Fluorescence in situ hybridization (FISH) for myelodysplastic syndrome (MDS), targeting numerical changes associated with 5q, 7q, 8, and 20q.
Special Instructions
Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form.
Expected Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Blood, bone marrow, fixed-cell pellet from a cytogenetic analysis, or slides prepared from a cytogenetic analysis
Volume
10 mL blood (adult), 3 to 5 mL blood (pediatric), 1 to 3 mL bone marrow, one fixed-cell pellet, or four slides
Minimum Volume
1 mL blood (adult/pediatric), 1 mL bone marrow, or four slides
Container
Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Broken Vacutainer®; broken slides
Test Details
Use
Diagnostic test for myelodysplastic syndrome. The principal use is for interphase analysis of cases with no (or low) mitotic activity in cytogenetic analysis or interphase analysis from blood in cases of inaspirable bone marrow. Detection rate is approximately 80% of clones detected in cytogenetic analysis.
Methodology
Fluorescence in situ Hybridization (FISH)
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 511060 | MDS FISH Panel | 510616 | Cells Counted | 62361-1 | ||
| 511060 | MDS FISH Panel | 510617 | Cells Analyzed | 62360-3 | ||
| 511060 | MDS FISH Panel | 510618 | FISH Result | 57802-1 | ||
| 511060 | MDS FISH Panel | 511042 | Interpretation | 50398-7 | ||
| 511060 | MDS FISH Panel | 510620 | Specimen Type | 31208-2 | ||
| 511060 | MDS FISH Panel | 511038 | Director Review: | 48672-0 |
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