Chromosome Analysis, Leukemia/Lymphoma

TEST: 510999
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CPT: Contact CPT coding department at 800-222-7566, ext 6-8400.
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Synonyms

  • Chromosome Analysis, Hematologic Disorders
  • Lymphoma

Test Includes

Short-term and, in some cases, long-term β-mitogen culturing of specimens, chromosome preparation, and analysis of 20 metaphases; multiple karyotypes prepared, including all abnormal clones

Special Instructions

Include tentative diagnosis/treatment on the test request form. This is necessary for proper culturing and result interpretation. If plasma-enriched Multiple Myeloma (MM) Profile, FISH [510325] is ordered concurrently and sample is not sufficient for both tests, FISH will be prioritized. Please direct any questions regarding this test to customer service at 800-345-4363.

Expected Turnaround Time

7 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Bone marrow, blood (>4% blasts required − see Collection), lymph node, spleen, bone core, or effusion

Volume

2 mL bone marrow, 3 mL peripheral blood, or 0.5 to 1 cm³ tissue biopsy

Container

Bone marrow or peripheral blood in pediatric sodium heparin green-top tube; lymph node, spleen, bone core, CSF, or effusion in lymph node transport bottle

Collection

The requirement of >4% blasts for blood does not apply to cases of CLL, hairy cell leukemia, and some cases of small-cell lymphocytic leukemia (SCLL) or lymphoma, which can be β-mitogen stimulated. Submit bone marrow or peripheral blood at room temperature using Leukemia/Lymphoma Specimen Transport Kit (supplied by LabCorp). Submit lymph node, spleen, or bone core at room temperature using Lymph Node Transport Kit (supplied by LabCorp). Effusions may be sent in small sterile containers. Specimens should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on the test request form.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Hemolysis; gross contamination; non-neoplastic cells; clotted specimen; frozen specimen; fixed specimen; improper or too much anticoagulant

Test Details

Use

Karyotyping, physical localization of copy number changes, and mapping of breakpoints involved in translocations.

Limitations

Use of lithium heparin (or EDTA) will inhibit growth of cell culture.

Methodology

Short-term cell culture; synchronization; chromosome harvest; G-banding; analysis (20 metaphases) and karyotyping; long-term β-mitogen cultures in some B-cell leukemias

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510999 Chromosome, Leukemia/Lymphoma 510678 Specimen Type 31208-2
510999 Chromosome, Leukemia/Lymphoma 510679 Cells Counted 62361-1
510999 Chromosome, Leukemia/Lymphoma 510680 Cells Analyzed 62360-3
510999 Chromosome, Leukemia/Lymphoma 510681 Cells Karyotyped 55199-4
510999 Chromosome, Leukemia/Lymphoma 510682 GTG Band Resolution Achieved 62358-7
510999 Chromosome, Leukemia/Lymphoma 510683 Cytogenetic Result 62356-1
510999 Chromosome, Leukemia/Lymphoma 510992 Interpretation 62365-2
510999 Chromosome, Leukemia/Lymphoma 510993 Director Review: 48672-0
510999 Chromosome, Leukemia/Lymphoma 512123 PDF 51967-8

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf