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Synonyms
- Acute Lymphoblastic Leukemia; Leukemia/Lymphoma-specific FISH
Test Includes
Fluorescence in situ hybridization (FISH) for acute lymphoblastic leukemia (ALL), targeting rearrangement of BCR/ABL, KMT2A (MLL), CMYC and numerical changes of chromosome 6 and 21q deletion
Special Instructions
Include the pertinent clinical diagnosis and previous cytogenetic studies with the test request form.
Expected Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei or bone marrow touch preparation slides are acceptable for testing.
Volume
10 mL blood (pediatric), 3 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 8 slides with metaphase and/or interphase nuclei or 8 touch preparation slides.
Minimum Volume
5 mL blood (pediatric), 1 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 4 slides with metaphase and/or interphase nuclei or 4 touch preparation slides. (Note: Minimum volumes may not allow for repeat testing.)
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). Adjust tube size to sample volume to avoid heparin toxicity.
Collection
Transport to the testing laboratory at room temperature, use of a cool pack or a LabCorp transport kit is acceptable. Do not allow samples to overheat or freeze.
Storage Instructions
Maintain the specimen at either room temperature or refrigerate. Do not freeze.
Causes for Rejection
Broken Vacutainer®; broken or stained slides; paraffin blocks; paraffin slides; decalcified bone cores; frozen specimen; quantity not sufficient for analysis
Test Details
Use
Diagnostic and prognostic test for acute lymphoblastic leukemia in the pediatric population; detection rate is improved from 50% with a chromosome study to 90% with fluorescence in situ hybridization (FISH)
Methodology
Fluorescence in situ hybridization (FISH)
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 511077 | FISH Adult ALL Oncology | 511059 | Specimen Type | 31208-2 | ||
| 511077 | FISH Adult ALL Oncology | 511061 | Cells Counted | 62361-1 | ||
| 511077 | FISH Adult ALL Oncology | 511068 | Cells Analyzed | 62360-3 | ||
| 511077 | FISH Adult ALL Oncology | 511069 | FISH Result | 62356-1 | ||
| 511077 | FISH Adult ALL Oncology | 511073 | Interpretation | 62365-2 | ||
| 511077 | FISH Adult ALL Oncology | 511076 | Director Review: | 48672-0 | ||
| 511077 | FISH Adult ALL Oncology | 512123 | 51967-8 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf