High-Grade B-Cell Lymphoma, FISH

TEST: 510344
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CPT: Contact CPT coding department at 800-222-7566, ext. 6-8400.
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Contact CPT coding department at 800-222-7566, ext. 6-8400.
Updated on 11/6/2024
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Test Includes

This test includes fluorescence in situ hybridization (FISH) for high-grade B-cell lymphoma, targeting rearrangement of BCL2, BCL6 and MYC.

Fluorescence in situ hybridization (FISH) for aggressive B‐cell lymphoma, targeting rearrangement of BCL2, BCL6, and MYC

This test includes fluorescence in situ hybridization (FISH) for high-grade B-cell lymphoma, targeting rearrangement of BCL2, BCL6 and MYC.

Special Instructions

Indicate the pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the laboratory.

Expected Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Blood, bone marrow, slides, paraffin block, lymph node or touch preps

Blood, bone marrow, slides, paraffin block, lymph node, or touch preps

Blood, bone marrow, slides, paraffin block, lymph node or touch preps

Volume

7 mL blood (adult), 1-3 mL bone marrow, five slides from cytogenetic analysis or seven slides from paraffin block, one tube fixed pellet, 4 touch prep slides

Minimum Volume

1 mL blood, 1 mL bone marrow, and four- to five-micron FFPE slides, 5 touch prep slides

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Storage Instructions

Maintain specimens at room temperature.

Causes for Rejection

Broken Vacutainer®; broken slides

Test Details

Use

This test is a diagnostic test for non-Hodgkin's lymphoma (NHL) that detects primary genetic changes associated with various types of NHL, including high-grade B-cell lymphoma, follicular lymphoma (FL), Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and those with BCL6 rearrangement.

Diagnostic test for non-Hodgkin’s lymphoma (NHL). Detects primary genetic changes associated with various types of NHL, including follicular lymphoma (FL), Burkitt's lymphoma (BL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), and those with BCL6 rearrangement.

This test is a diagnostic test for non-Hodgkin's lymphoma (NHL) that detects primary genetic changes associated with various types of NHL, including high-grade B-cell lymphoma, follicular lymphoma (FL), Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and those with BCL6 rearrangement.

Limitations

Molecular mutations below the resolution of FISH will not be detected.

Methodology

Fluorescence in situ hybridization (FISH)

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