High-Grade B-Cell Lymphoma, FISH

TEST: 510344
Test number copied
CPT: Contact CPT coding department at 800-222-7566, ext. 6-8400.
Print Share

Test Includes

This test includes fluorescence in situ hybridization (FISH) for high-grade B-cell lymphoma, targeting rearrangement of BCL2, BCL6 and MYC.

Special Instructions

Indicate the pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the laboratory.

Expected Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Blood, bone marrow, slides, paraffin block, lymph node or touch preps

Volume

7 mL blood (adult), 1-3 mL bone marrow, five slides from cytogenetic analysis or seven slides from paraffin block, one tube fixed pellet, 4 touch prep slides

Minimum Volume

1 mL blood, 1 mL bone marrow, and four- to five-micron FFPE slides, 5 touch prep slides

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Storage Instructions

Maintain specimens at room temperature.

Causes for Rejection

Broken Vacutainer®; broken slides

Test Details

Use

This test is a diagnostic test for non-Hodgkin's lymphoma (NHL) that detects primary genetic changes associated with various types of NHL, including high-grade B-cell lymphoma, follicular lymphoma (FL), Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and those with BCL6 rearrangement.

Limitations

Molecular mutations below the resolution of FISH will not be detected.

Methodology

Fluorescence in situ hybridization (FISH)

LOINC® Map

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf