Chronic Myelogenous Leukemia (CML) Profile: Chromosome Analysis and BCR-ABL, FISH

TEST: 150500
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CPT: Contact CPT coding department at 800-222-7566, ext 6-8400. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Synonyms

  • BCR-ABL FISH and Chromosome Analysis
  • Chromosome Analysis and BCR-ABL FISH
  • Philadelphia Chromosome

Test Includes

BCR-ABL for chronic myelogenous leukemia (CML), FISH; chromosome analysis; quantitative monitoring for CML by FISH; ABL deletions are confirmed by linked ASS analysis.

Special Instructions

Please direct any questions regarding this test to oncology customer service at 800-345-4363. Please note that the chromosome portion of this profile is generally not successful on peripheral blood samples from CML patients receiving imatinib (Gleevec®).

Expected Turnaround Time

7 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Specimen Requirements

Specimen

Bone marrow or peripheral blood

Volume

2 mL bone marrow or 3 mL peripheral blood

Container

Pediatric green-top (heparin) tube

Collection

Submit at room temperature using Leukemia/Lymphoma Specimen Transport Kit (supplied by LabCorp). Specimens should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on the test request form.

Storage Instructions

Maintain specimen at room temperature.

Test Details

Use

Confirm the diagnosis of chronic myelogenous leukemia; establish the chronic-phase karyotype for comparison with blast crisis alterations; monitor residual disease

Methodology

Cytogenetics; fluorescence in situ hybridization (FISH)

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
150500 CML Chromosome/FISH Profile 150414 Cells Counted 62361-1
150500 CML Chromosome/FISH Profile 150415 Cells Analyzed 62360-3
150500 CML Chromosome/FISH Profile 150416 FISH Result 51867-0
150500 CML Chromosome/FISH Profile 510977 Interpretation 50398-7
150500 CML Chromosome/FISH Profile 150418 Specimen Type 31208-2
150500 CML Chromosome/FISH Profile 510978 Director Review: 48672-0
150500 CML Chromosome/FISH Profile 512123 PDF 51967-8
150500 CML Chromosome/FISH Profile 510678 Specimen Type 31208-2
150500 CML Chromosome/FISH Profile 510679 Cells Counted 62361-1
150500 CML Chromosome/FISH Profile 510680 Cells Analyzed 62360-3
150500 CML Chromosome/FISH Profile 510681 Cells Karyotyped 55199-4
150500 CML Chromosome/FISH Profile 510682 GTG Band Resolution Achieved 62358-7
150500 CML Chromosome/FISH Profile 510683 Cytogenetic Result 62356-1
150500 CML Chromosome/FISH Profile 510992 Interpretation 62365-2
150500 CML Chromosome/FISH Profile 510993 Director Review: 48672-0

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf