Herpes Simplex Virus Type 1 (HSV-1), Type Specific Antibodies, IgG

0.5 mL

1.0 mL

Red-top tube or gel-barrier tube

Red-top tube, gel-barrier tube or serum transfer tube

Qualititative detection of IgG antibodies specific to HSV type 1 infection; confirm or rule out possible infection with herpes simplex type 1 virus in prenatal patients. In a patient with no history of lesion disease, a positive result for this test may be indicative that the primary infection was asymptomatic. Once infected by HSV, it is possible for a patient to shed virus without the development of lesions (asymptomatic shedding). This test does not indicate the site of HSV infection. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample.

This test is used for qualitative detection of IgG antibodies specific to HSV type 1. This test is intended for sexually active individuals and pregnant individuals as an aid in the presumptive diagnosis of HSV-1 infection. The test results may not determine the state of active lesions or associated disease manifestations, particularly in primary infection. The predictive value of positive an negative results depends on the population's prevalence and the pretest likelihood of HSV-1. The detection of HSV-1 IgG antibodies in a single sample indicates a previous exposure to HSV-1 but does not give information as to the site of HSV infection or the timing of exposure.

There is a considerable homology between HSV-1 and HSV-2 antigens, so that antibodies formed against either virus are highly crossreactive. This assay is based on purified recombinant glycoprotein G-1 and is specific for type 1 antibodies. Moreover, this assay is highly sensitive and specific and will not detect antibodies to HSV-2.

Chemiluminescent immunoassay (CLIA)

Electrochemiluminescience immunoassay (ECLIA)