EORTC-NCI-AACR (ENA) Symposium 2024 -- Mouse tumor models play an essential role in investigating tumor biology, evaluating therapeutic response and predicting clinical outcomes. The location of the tumor, whether implanted subcutaneously or orthotopically, can significantly impact its growth, spread and response to treatment. The MC38-luc mouse colon carcinoma model is widely used in preclinical cancer research for studying tumor biology and immunotherapy responses. The aim of this study was to evaluate the antitumor efficacy and immunomodulatory effects of immune checkpoint inhibitors (ICIs) in subcutaneous (SC) and orthotopic (OT) MC38-luc mouse models.

• Download