Human Immunodeficiency Virus 1 (HIV-1) Trofile® DNA (Monogram® Coreceptor Tropism), Whole Blood

TEST: 829670
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Expected Turnaround Time

29 - 33 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

HIV Specimen Collection Guide

HIV-1 Lifecycle, Drugs, and Susceptibility Assays

Supporting Individualized HIV Treatment Decisions

Specimen Requirements

Specimen

Whole blood, frozen

Volume

4 mL

Container

Lavender-top (EDTA) tube

Collection

Collect specimen in lavender-top (EDTA) tube. Do not centrifuge. Ship frozen. To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze.

Causes for Rejection

Insufficient volume; heparinized plasma; nonfrozen specimen

Test Details

Use

Detect HIV-1 coreceptor tropism; determine eligibility for CCR5 antagonist therapy such as Selzentry™ (maraviroc).

Limitations

This procedure should be used for patients with documented HIV-1 infection and undetectable viral loads.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Polymerase chain reaction (PCR) amplification and viral culture. Trofile™ is a registered trademark of Monogram Biosciences.

References

Whitcomb JM, Huang W, Fransen S, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother. 2007 Feb; 51(2):566-575. 17116663

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
829670 Trofile(R) DNA 550341 Trofile(R) DNA PDF 51969-4
829670 Trofile(R) DNA 550347 Tropotype: 80690-1
829670 Trofile(R) DNA 829671 Trofile(R) DNA 50790-5
829670 Trofile(R) DNA 829672 Trofile(R) DNA Interpretation 62364-5

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