ANA 12 Profile, Do All (RDL)

CPT: 86038; 86147(x3); 86160(x2); 86225; 86235(x6); 86376
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Synonyms

  • ANA 12
  • ANA 12 Panel

Test Includes

This profile is comprised of Anti‐Nuclear Ab (ANA) by IFA, Anti‐dsDNA Ab by Farr, Anti‐ENA Abs (Anti‐Sm & Anti‐RNP), Anti‐Centromere Ab, C3 & C4 Complements, Anti‐Ro (SS‐A) Ab, Anti‐La (SS‐B) Ab, Anti‐Scl‐70 Ab, Anti‐cardiolipin Abs (IgG, IgA & IgM isotypes), Anti‐TPO (Thyroid Microsomal Peroxidase) Ab, Anti‐Chromatin Ab.


Expected Turnaround Time

14 - 21 days



Specimen Requirements


Specimen

Serum


Volume

4 mL


Minimum Volume

1.5 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Refrigerate or freeze.


Stability Requirements

Temperature

Room temperature

Period

7 days

Refrigerated

Period

14 days

Frozen

Period

60 days

Freeze/thaw cycles

Period

Stable x1

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1


Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types


Test Details


Use

The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic and potential prognostic utility for several autoimmune diseases.

RDL’s ANA 12 Profile Helps Differentiate Between 8 Autoimmune Disease States:

SLE

• ANA by IFA

Tests with high specificity

• Anti-dsDNA by Farr

• Anti-SM

Tests with moderate specificity

• Anti-Ro

• Anti-La

• C3 & C4 Complements

• Anticardiolipin IgG, IgA & IgM

Sjogren’s Syndrome

• Anti-Ro

• Anti-La

Mixed Connective Tissue Disease (MCTD)

• Anti-U1 RNP

Limited Scleroderma (CREST)

• Anti-Centromere

Diffuse Scleroderma

• Anti-SCL-70 by EIA, confirmed by ID

Autoimmune Thyroid Disease


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

See individual test components.


LOINC® Map

Order Code
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520073
Result Code NameAnti-Nuclear Ab by IFA (RDL)
Result LOINC42254-3
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520066
Result Code NameAnti-Centromere Ab by IFA(RDL)
Result LOINC5077-3
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520060
Result Code NameAnti-dsDNA Ab by Farr(RDL)
UofMIU/mL
Result LOINC47299-3
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520216
Result Code NameAnti-Sm Ab (RDL)
UofMUnits
Result LOINC11090-8
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520217
Result Code NameAnti-U1 RNP Ab (RDL)
UofMUnits
Result LOINC57662-9
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520218
Result Code NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520225
Result Code NameAnti-La (SS-B) Ab (RDL)
UofMUnits
Result LOINC45142-7
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520221
Result Code NameAnti-Scl-70 Ab (RDL)
UofMUnits
Result LOINC26975-3
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520223
Result Code NameAnti-Cardiolipin Ab, IgG (RDL)
UofMGPL U/mL
Result LOINC3181-5
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520182
Result Code NameAnti-Cardiolipin Ab, IgA (RDL)
UofMAPL U/mL
Result LOINC5076-5
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520183
Result Code NameAnti-Cardiolipin Ab, IgM (RDL)
UofMMPL U/mL
Result LOINC3182-3
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520169
Result Code NameC3 Complement (RDL)
UofMmg/dL
Result LOINC4485-9
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520167
Result Code NameC4 Complement (RDL)
UofMmg/dL
Result LOINC4498-2
520299
Order Code NameANA 12 Profile, Do All RDL
Result Code520036
Result Code NameAnti-TPO Ab (RDL)
UofMIU/mL
Result LOINC8099-4
Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520299 ANA 12 Profile, Do All RDL 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
520299 ANA 12 Profile, Do All RDL 520066 Anti-Centromere Ab by IFA(RDL) 5077-3
520299 ANA 12 Profile, Do All RDL 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
520299 ANA 12 Profile, Do All RDL 520216 Anti-Sm Ab (RDL) Units 11090-8
520299 ANA 12 Profile, Do All RDL 520217 Anti-U1 RNP Ab (RDL) Units 57662-9
520299 ANA 12 Profile, Do All RDL 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
520299 ANA 12 Profile, Do All RDL 520225 Anti-La (SS-B) Ab (RDL) Units 45142-7
520299 ANA 12 Profile, Do All RDL 520221 Anti-Scl-70 Ab (RDL) Units 26975-3
520299 ANA 12 Profile, Do All RDL 520223 Anti-Cardiolipin Ab, IgG (RDL) GPL U/mL 3181-5
520299 ANA 12 Profile, Do All RDL 520182 Anti-Cardiolipin Ab, IgA (RDL) APL U/mL 5076-5
520299 ANA 12 Profile, Do All RDL 520183 Anti-Cardiolipin Ab, IgM (RDL) MPL U/mL 3182-3
520299 ANA 12 Profile, Do All RDL 520169 C3 Complement (RDL) mg/dL 4485-9
520299 ANA 12 Profile, Do All RDL 520167 C4 Complement (RDL) mg/dL 4498-2
520299 ANA 12 Profile, Do All RDL 520036 Anti-TPO Ab (RDL) IU/mL 8099-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520074
Homogeneous Pattern
20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520074 Homogeneous Pattern 20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520076
Nucleolar Pattern
20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520076 Nucleolar Pattern 20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520233
Speckled Pattern
20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520233 Speckled Pattern 20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520234
Centromere Pattern
53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520234 Centromere Pattern 53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520235
Spindle Apparatus Pattern
53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520235 Spindle Apparatus Pattern 53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520236
Nuclear Membrane Pattern
54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520236 Nuclear Membrane Pattern 54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520237
Midbody Pattern
54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520237 Midbody Pattern 54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520238
Nuclear Dot Pattern
53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520238 Nuclear Dot Pattern 53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520239
PCNA Pattern
53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520239 PCNA Pattern 53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520240
Centriole Pattern
53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520240 Centriole Pattern 53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520077
ANA Titer and Pattern
520241
Note:
77202-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520241 Note: 77202-0
Reflex Table for Anti-Scl-70 Ab (RDL)
Order Code
Order Name
Result Code
Result Name
UofM
Result LOINC
Reflex 1
520341
Repeat Anti-Scl-70
520341
Repeat Anti-Scl-70
5348-8
Reflex Table for Anti-Scl-70 Ab (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520341 Repeat Anti-Scl-70 520341 Repeat Anti-Scl-70 5348-8

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