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Synonyms
- ANA 12
- ANA 12 Panel
Test Includes
ANA Profile 12 is reflexive and is comprised of Anti-Nuclear Ab (ANA) by IFA, Anti-Cardiolipin Ab (IgG, IgA & IgM Isotypes), Anti-Centromere Ab, Anti-dsDNA Ab by Farr, Anti-La (SS-B) Ab, Anti-Ro (SSA) Ab, Anti-Scl-70 Ab, Anti- Sm, Anti-TPO (Thyroid Microsomal Peroxidase) Ab, Anti-U1 RNP, C3 Complement, C4 Complement.
If ANA is positive, all tests listed are performed. If ANA is negative, an Anti-Ro (SS-A) test is performed to catch the small percentage of ANA false negative results. ANA includes titer & pattern.
Expected Turnaround Time
10 - 12 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Antinuclear Antibodies Testing Options in Rheumatology Brochure
Specimen Requirements
Specimen
Serum
Volume
5 mL
Minimum Volume
4 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 8 days |
Refrigerated | 8 days |
Frozen | 8 days |
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Test Details
Use
The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic and potential prognostic utility for several autoimmune diseases.
RDL’s ANA 12 Profile Helps Differentiate Between 8 Autoimmune Disease States:
SLE
• ANA by IFA
Tests with high specificity
• Anti-dsDNA by Farr
• Anti-SM
Tests with moderate specificity
• Anti-Ro
• Anti-La
• C3 & C4 Complements
• Anticardiolipin IgG, IgA & IgM
Sjogren’s Syndrome
• Anti-Ro
• Anti-La
Mixed Connective Tissue Disease (MCTD)
• Anti-U1 RNP
Limited Scleroderma (CREST)
• Anti-Centromere
Diffuse Scleroderma
• Anti-SCL-70 by EIA, confirmed by ID
Autoimmune Thyroid Disease
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
ELISA, IFA, Farr RIA,CMIA
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520188 | ANA Profile 12 (RDL) | 42254-3 | 520073 | Anti-Nuclear Ab by IFA (RDL) | 42254-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520066 | Anti-Centromere Ab by IFA(RDL) | 5077-3 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520060 | Anti-dsDNA Ab by Farr(RDL) | IU/mL | 47299-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520216 | Anti-Sm Ab (RDL) | Units | 11090-8 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520217 | Anti-U1 RNP Ab (RDL) | Units | 57662-9 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520225 | Anti-La (SS-B) Ab (RDL) | Units | 45142-7 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520221 | Anti-Scl-70 Ab (RDL) | Units | 26975-3 |
| Reflex 3 | 520341 | Repeat Anti-Scl-70 | 520341 | Repeat Anti-Scl-70 | 5348-8 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520223 | Anti-Cardiolipin Ab, IgG (RDL) | GPL U/mL | 3181-5 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520182 | Anti-Cardiolipin Ab, IgA (RDL) | APL U/mL | 5076-5 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520183 | Anti-Cardiolipin Ab, IgM (RDL) | MPL U/mL | 3182-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520169 | C3 Complement (RDL) | mg/dL | 4485-9 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520167 | C4 Complement (RDL) | mg/dL | 4498-2 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520036 | Anti-TPO Ab (RDL) | IU/mL | 8099-4 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520219 | Anti-Ro/Neg ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex 2 | 520177 | ANA 12 Profile, Positive Ro | 520229 | ANA 12 Profile Interpretation | N/A | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520074 | Homogeneous Pattern | 20398-4 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520076 | Nucleolar Pattern | 20399-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520233 | Speckled Pattern | 20401-6 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520234 | Centromere Pattern | 53993-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520235 | Spindle Apparatus Pattern | 53003-0 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520236 | Nuclear Membrane Pattern | 54006-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520237 | Midbody Pattern | 54155-7 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520238 | Nuclear Dot Pattern | 53998-1 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520239 | PCNA Pattern | 53006-3 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520240 | Centriole Pattern | 53993-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520241 | Note: | 77202-0 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520066 | Anti-Centromere Ab by IFA(RDL) | 5077-3 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520060 | Anti-dsDNA Ab by Farr(RDL) | IU/mL | 47299-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520216 | Anti-Sm Ab (RDL) | Units | 11090-8 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520217 | Anti-U1 RNP Ab (RDL) | Units | 57662-9 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520225 | Anti-La (SS-B) Ab (RDL) | Units | 45142-7 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520221 | Anti-Scl-70 Ab (RDL) | Units | 26975-3 |
| Reflex 2 | 520341 | Repeat Anti-Scl-70 | 520341 | Repeat Anti-Scl-70 | 5348-8 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520223 | Anti-Cardiolipin Ab, IgG (RDL) | GPL U/mL | 3181-5 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520182 | Anti-Cardiolipin Ab, IgA (RDL) | APL U/mL | 5076-5 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520183 | Anti-Cardiolipin Ab, IgM (RDL) | MPL U/mL | 3182-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520169 | C3 Complement (RDL) | mg/dL | 4485-9 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520167 | C4 Complement (RDL) | mg/dL | 4498-2 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520036 | Anti-TPO Ab (RDL) | IU/mL | 8099-4 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520179 | ANA 12 Profile, Positive ANA | 520229 | ANA 12 Profile Interpretation | N/A | |
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