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Synonyms
- CWD Resolution Typing
Special Instructions
If you have questions, please call 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.
Expected Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Whole blood or buccal swabs
Volume
7 mL whole blood or four buccal swabs
Minimum Volume
3 mL whole blood or four buccal swabs
Container
Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). When submitting buccal swabs, please use a buccal swab kit provided by LabCorp. To obtain the buccal swab kit, please telephone 800-533-1037.
Storage Instructions
Maintain specimen at room temperature; protect from extreme heat or cold. Do not freeze.
Causes for Rejection
Hemolyzed specimen; clotted specimen; wrong specimen container
Test Details
Use
Test provides data for clients to use for matching transplant donors and recipients. Specific HLA B alleles may be correlated with certain disease states or other clinical conditions. This test may be used to identify specific alleles (except for HLA B*15:02 [167129] and HLA B*57:01 [006926]).
CWD resolution typing for HLA will meet the following criteria:
1. The typing must contain only one unambiguously assigned genotype, or
2. The typing may contain multiple alternative genotypes if one includes two Common and Well Documented (CWD) alleles and the others do not include any CWD allele. Alleles that encode identical protein sequences in the antigen recognition site (ARS) will not be resolved even if they are CWD.
3. Rare or unusual allele combinations may not be ruled out.
4. Allele codes will be reported to include those alleles that are not ruled out.
Common and well documented alleles are defined by Cano et al1 and Mack et al.2
Limitations
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Methodology
Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.
Footnotes
1. Cano P, Klitz W, Mack SJ, et al. Common and well-documented HLA alleles: Report of the ad-hoc committee of the American Society for Histocompatibility and Immunogenetics. Hum Immunol. 2007 May; 68(5):392-417. 17462507
2. Mack SJ, Cano P, Hollenbach JA, et al. Common and Well-Documented HLA Alleles: 2012 Update to the CWD Catalogue. Tissue Antigens. 2013 Apr; 81(4):194-203. 23510415
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 167352 | HLA-B (CWD) | 167339 | HLA-B | 57291-7 | ||
| 167352 | HLA-B (CWD) | 167341 | HLA-B | 57291-7 | ||
| 167352 | HLA-B (CWD) | 167384 | HLA Methodology | 49549-9 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf