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Celiac Antibodies tTG IgA and Total IgA With Reflex to tTG IgG and DGP IgG

CPT 82784; 86364
Synonyms
  • IgA
  • Tissue Transglutaminase (tTG)

Test Details

Methodology

Enzyme immunoassay (EIA)

Result Turnaround Time

2 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Celiac Disease Testing Services

Use

Aid in the diagnosis of gluten-sensitive enteropathies

References

Agardh D. Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol. 2007 Nov;5(11):1276-1281.17683995
Biagi F, Pezzimenti D, Campanella J, Vadacca GB, Corazza GR. Endomysial and tissue transglutaminase antibodies in coeliac sera: a comparison not influenced by previous serologic testing. Scand J Gastroenterol. 2001 Sep;36(9):955-958.11521986
Burgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug;66(8):941-947.1819255
Calabuig M, Torregosa R, Polo P, et al. Serologic markers and celiac disease: a new diagnostic approach? Pediatr Gastroenterol Nutr. 1990 May;10(4):435-442.2193137
Green PH, Jabri B. Coeliac disease. Lancet. 2003 Aug 2;362(9381):383-391.12907013
Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005 Jan;40(1):1-19.15625418
Kaukinen K, Collin P, Laurila K, Kaartinen T, Partanen J, Maki M. Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit. Scand J Gastroenterol. 2007 Dec;42(12):1428-1433.17852878
National Institutes of Health Consensus Development Conference Statement on Celiac Disease, 2004.
Pruessner HT. Detecting celiac disease in your patients. Am Fam Physician. 1998 Mar 1;57(5):1023-1034, 1039-1041.9518950

Custom Additional Information

Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as 1% of the population in the United States. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, etc. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time.

Specimen Requirements

Specimen

Serum

Volume

3 mL

Minimum Volume

1 mL

Container

Red-top tube or gel-barrier tube

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Storage Instructions

Room temperature

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164047 Celiac Ab tTG TIgA w/Rflx 94493-4 164643 t-Transglutaminase (tTG) IgA U/mL 31017-7
164047 Celiac Ab tTG TIgA w/Rflx 94493-4 001784 Immunoglobulin A, Qn, Serum mg/dL 2458-8
Order Code164047
Order Code NameCeliac Ab tTG TIgA w/Rflx
Order Loinc94493-4
Result Code164643
Result Code Namet-Transglutaminase (tTG) IgA
UofMU/mL
Result LOINC31017-7
Order Code164047
Order Code NameCeliac Ab tTG TIgA w/Rflx
Order Loinc94493-4
Result Code001784
Result Code NameImmunoglobulin A, Qn, Serum
UofMmg/dL
Result LOINC2458-8
Reflex Table for Immunoglobulin A, Qn, Serum
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 164048 Glia(IgG)+tTG(IgG) 161693 Deamidated Gliadin Abs, IgG units 58710-5
Reflex 1
Order Code164048
Order NameGlia(IgG)+tTG(IgG)
Result Code161693
Result NameDeamidated Gliadin Abs, IgG
UofMunits
Result LOINC58710-5
Reflex Table for Immunoglobulin A, Qn, Serum
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 164048 Glia(IgG)+tTG(IgG) 164989 t-Transglutaminase (tTG) IgG U/mL 32998-7
Reflex 1
Order Code164048
Order NameGlia(IgG)+tTG(IgG)
Result Code164989
Result Namet-Transglutaminase (tTG) IgG
UofMU/mL
Result LOINC32998-7