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Multiple Sclerosis (MS) Profile With Myelin Basic Protein, Cerebrospinal Fluid
CPT:
82040; 82042; 82784(x2); 83873; 83916
Synonyms
- MS Profile
Test Includes
IgG and albumin quantitation in both serum and spinal fluid samples; CSF IgG:CSF albumin ratio; CSF IgG index; CSF IgG synthesis rate; myelin basic protein (CSF); oligoclonal banding
Expected Turnaround Time
4 - 9 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum and cerebrospinal fluid (CSF), collected at the same time
Volume
2 mL serum and 2.5 mL CSF
Minimum Volume
0.8 mL serum and 1.4 mL CSF
Profile Components | CSF Preferred | CSF Minimum | Serum Preferred | Serum Minimum | Notes |
|---|---|---|---|---|---|
*IgG synthesis rate and IgG:albumin ratio (CSF) within the multiple sclerosis profile utilize the same IgG and albumin (CSF and serum) results from the IgG index for calculations; therefore, no additional sample is required. | |||||
Myelin basic protein (MBP) | 1 mL | 0.8 mL | N/A | N/A | |
Oligoclonal banding | 0.5 mL | 0.1 mL | 0.5 mL | 0.1 mL | Serum and CSF must be collected at the same time. |
IgG index* | 1 mL | 0.5 mL | 1.5 mL | 0.7 mL | Includes IgG and albumin on CSF and serum |
Total sample required | 2.5 mL | 1.4 mL | 2 mL | 0.8 mL | |
Container
Plastic transport tubes
Collection
Collect serum and CSF at the same time. Avoid contaminating CSF with blood. Centrifuge CSF at 1500xg for 20 minutes and place the supernatant into separate tubes. Ensure residual fibrin and cellular matter have been removed.
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x2 |
Causes for Rejection
Plasma instead of serum specimen; serum and CSF not collected within eight hours of each other; lipemic, hemolyzed, or icteric CSF specimen
Test Details
Use
Adjunct in aiding clinical diagnosis of multiple sclerosis
Limitations
Results for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.
Methodology
MBP: enzyme-linked immunosorbent assay (ELISA); oligoclonal banding: IEF; CSF IgG, CSF albumin, and serum IgG: immunologic; serum albumin: spectrophotometry; synthesis rate, ratio, and index by calculation
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 123390 | MS Profile+MBP, CSF | 012212 | IgG, Quant, CSF | mg/dL | 2464-6 | |
| 123390 | MS Profile+MBP, CSF | 012230 | Albumin, CSF | mg/dL | 1746-7 | |
| 123390 | MS Profile+MBP, CSF | 001081 | Albumin | g/dL | 1751-7 | |
| 123390 | MS Profile+MBP, CSF | 001776 | Immunoglobulin G, Qn, Serum | mg/dL | 2465-3 | |
| 123390 | MS Profile+MBP, CSF | 160311 | IgG/Alb Ratio, CSF | 2470-3 | ||
| 123390 | MS Profile+MBP, CSF | 101124 | CSF IgG Index | 14117-6 | ||
| 123390 | MS Profile+MBP, CSF | 085937 | IgG, Syn Rate,CSF | mg/day | 14116-8 | |
| 123390 | MS Profile+MBP, CSF | 123378 | Myelin Basic Protein, CSF | ng/mL | 2638-5 | |
| 123390 | MS Profile+MBP, CSF | 111237 | Oligoclonal Bands | N/A | ||
| 123390 | MS Profile+MBP, CSF | 111666 | Oligoclonal Bands | 48668-8 | ||
| 123390 | MS Profile+MBP, CSF | 120173 | CSF/Serum Alb. Index | 1756-6 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf