Challenges when designing qPCR/ddPCR assays for cell and gene therapies

While designing a qPCR/ddPCR assay for supporting cell and gene therapies can be straight forward, there are also key challenges and complexities molecular bioanalytical scientists currently face in the process. This webinar will review and discuss these challenges and complexities via key examples, the approaches taken to overcome them to drive the best outcomes, as well as a future outlook on how the field continues to evolve. New drug modalities continue to accelerate beyond therapeutic proteins and into cellular and molecular medicines, resulting in the introduction of new bioanalytical methods to support their advancement. Flow cytometry, polymerase chain reaction, ELISpot, neutralizing antibodies for AAV and other viral vectors, and the promise for precision medicine/cures for some of the most challenging diseases have resulted in the introduction of a variety of technologies to stretch the boundaries of current pharmacokinetic and immunogenicity assessments.