1st Trimester Preeclampsia Screen

CPT: 81599

To be determined. Updates will be made when available.

81599

Updated on 11/15/2024

Synonyms

Preeclampsia, First Trimester


Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. The following information must also be provided: patient's weight and height, patient's date of birth, four blood pressure measurements (two from each arm) or mean arterial pressure (MAP), uterine artery pulsatility index (UtAPI is optional) and number of fetuses. Also indicate relevant patient history (i.e., prior history of preeclampsia, diabetes, smoking status). Serum testing is provided from 11.0 to 14.0 weeks gestation. The UtAPI measurement is optional but desired and if provided must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided.

 

 

 

 

For test inquiries, call CMBP genetic services at 800-345-4363. Client must provide a fetal nuchal translucency (NT) measurement and crown rump length (CRL) measurement. The NT measurement must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided. 

The following information must also be provided: patient's weight and height, patient's date of birth, four blood pressure measurements (two from each arm) or mean arterial pressure, uterine artery pulsatility index (UtAPI) and number of fetuses. Also indicate relevant patient history (i.e., prior history of preeclampsia, diabetes, smoking status). Serum testing is provided from 11.0 to 14.0 weeks gestation. NT can be assessed when the CRL is 45 to 84 mm.

For test inquiries, call CMBP genetic services at 800-345-4363. The following information must also be provided: patient's weight and height, patient's date of birth, four blood pressure measurements (two from each arm) or mean arterial pressure (MAP), uterine artery pulsatility index (UtAPI is optional) and number of fetuses. Also indicate relevant patient history (i.e., prior history of preeclampsia, diabetes, smoking status). Serum testing is provided from 11.0 to 14.0 weeks gestation. The UtAPI measurement is optional but desired and if provided must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided.

 

 

 

 


Expected Turnaround Time

2 - 5 days


Specimen Requirements


Specimen

Serum


Volume

3 mL


Minimum Volume

1 mL


Container

Gel-barrier tube


Collection

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory frozen (preferred) or refrigerated.


Storage Instructions

Frozen (preferred) or refrigerated


Stability Requirements

TemperaturePeriod
Room temperatureUnstable
Refrigerated10 days
Frozen10 days
Freeze/thaw cyclesStable x3

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type; received at room temperature


Test Details


Use

This test is a screening test for the development of preeclampsia prior to 34 weeks of pregnancy.


Limitations

This is a screening test for preeclampsia to classify patients as low or high risk to develop preeclampsia later in pregnancy. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.


Methodology

Fluoroimmunometric assay


References

Tan MY, Wright D, Syngelaki A, et al. Comparison of diagnostic accuracy of early screening for pre-eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE. Ultrasound Obstet Gynecol. 2018 Jun;51(6):743-750. PubMed 29536574
 


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