Narcolepsy Evaluation

TEST: 167655
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CPT: 81383(x2)
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Special Instructions

If you have questions, please call HLA customer service at 800-533-1037 for assistance in selecting the appropriate HLA test for the patient.

Expected Turnaround Time

3 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Whole blood or buccal swabs

Volume

7 mL or four buccal swabs

Minimum Volume

3 mL or four buccal swabs

Container

Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). If submitting buccal swabs, please use the kit provided by Labcorp. To obtain the buccal swab kit or to discuss other specimen types, please call 800-533-1037.

Collection

Standard phlebotomy procedures or follow buccal swab kit instructions

Storage Instructions

Maintain specimen at room temperature. Protect from extreme heat or cold.

Causes for Rejection

Improper collection tube; mislabeled specimen

Test Details

Use

HLA DQB1*06:02 and HLA DQA1*01:02 are associated statistically with narcolepsy and are sometimes used as tests in support of that diagnosis.

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Next-generation sequencing or other methods as needed

References

Mignot E, Lin L, Rogers W, et al. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet. 2001 Mar;68(3):686-699. PubMed 11179016

For Providers

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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf